We did a fairly simple test by editing from AutoCAD:
(command "rectangle" (list 0 0 0) (list 20 20))
It's a French command to make a 20 by 20 rectangle at the origin point 0, 0, 0.
We then entered this line into the DrafSight command bar.
I'll let you judge the result ;)!
After that, it was a basic AutoCAD command, we don't know if this command is really native to the software.
In our programming, a lot of dynamic blocks have been used, and it seems to me that DrafSight doesn't use its blocks, so we'll still have a big loss of automation!
To make your work easier, I have created an Excel file with the names of the DraftSight and AutoCAD 2012 commands with a comparison (if they exist in the other software or not).